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PeptideGeek

Growth hormone

Hexarelin, explained simply

A powerful synthetic peptide that tells your pituitary gland to release more growth hormone — with heart-protective properties that make it stand out among GH boosters.

Some human studiesInjection under the skin (like insulin shots)17 cited sourcesResearch compound — not FDA approved

Start here

What is Hexarelin?

Hexarelin is a lab-made peptide that prompts the pituitary (the master hormone gland at the base of the brain) gland to release a burst of growth hormone by mimicking ghrelin, the hunger hormone. What sets it apart from similar peptides is that it also binds a second receptor, CD36, on heart cells — a connection research has linked to heart-protective effects 5. It is a research compound with early-stage human trial evidence, not an FDA-approved medicine.

How it works in your body

Think of Hexarelin as a master key that unlocks your body's growth hormone release. It works by mimicking ghrelin (your hunger hormone) and binding to special receptors in your pituitary (the master hormone gland at the base of the brain) gland called GHSR-1a. When it connects, it tells your pituitary to release a big burst of growth hormone into your bloodstream. 613 But here's what makes Hexarelin special: it also binds to another receptor called CD36 on your heart cells, which triggers protective pathways that help keep your heart healthy—something most other GH peptides don't do 5.

The deeper mechanism, for the curious

Hexarelin is a lab-made chain of six amino acids (the building blocks of proteins) that tells the body to release growth hormone (GH) 12. It works mainly by attaching to GHSR-1a, a docking site (receptor) for the hunger hormone ghrelin (the hunger hormone). Step by step: it attaches to GHSR-1a in the front part of the pituitary (the master hormone gland at the base of the brain) gland, which switches on a chain of signals inside the cell (phospholipase C, then IP3, then a rise in calcium), and the cell releases GH 13. Unlike ghrelin, hexarelin resists breakdown by enzymes, so it stays in the body more steadily 512. Among GH-releasing drugs, only hexarelin also attaches to CD36, a receptor found in heart tissue 5. CD36 gives heart protection that does not depend on GH. It lowers oxidative stress (cell damage from unstable molecules) 3. It shifts the autonomic nervous system (the body's automatic control system) toward its calming, rest-and-digest side 1. It blocks the NF-κB pathway (an inflammation switch). And it reduces scarring of heart muscle (myocardial fibrosis) by suppressing TGF-β1 (a scar-promoting signal) 1. The GHSR-1a pathway also affects metabolism: it speeds up fat breakdown in fat tissue and reduces the liver's making of new fat, which helps body composition and insulin sensitivity (how well the body responds to insulin) 2.

Evidence check

Some human studies

It has been tested in people, but only in small or early-stage studies. Promising, but not yet proven the way an approved medicine is.

Every numbered marker on this page links to one of the 17 sources at the bottom.

96/100

Growth Hormone Release

One of the most potent growth hormone secretagogues available—triggers robust, pulsatile GH release that mimics natural youthful patterns

92/100

Heart Health

Unique heart-protecting effects by switching on CD36 (a docking site on heart cells): reduces inflammation and protects heart cells from damage

88/100

Body Composition

Helps the body burn fat, reduces deep belly fat, and helps hold on to lean mass by improving growth hormone activity

What the research points to

  • Triggers strong pulses of growth hormone release from your pituitary (the master hormone gland at the base of the brain) gland (a small gland at the base of the brain)
  • Supports heart health with heart-protecting effects not seen in other growth hormone peptides
  • May help reduce body fat by increasing fat burning and decreasing fat storage
  • Promotes muscle growth and helps preserve lean mass
  • Supports faster recovery after workouts or injuries
  • May improve sleep quality through growth hormone's natural sleep-enhancing effects

The most-asked question

How much Hexarelin do I take?

The research-reported range is 1.5–3 mcg/kg, once daily. Studies used different doses for different situations — find yours:

  1. GH secretagogue (research)

    1.5-3 mcg/kg (approx. 100-200 mcg); ~100 mcg per injection in practice

    • How often
      Single dose in trials; 1-3 times daily in research practice
    • For how long
      One-off test, or no set end date in everyday practice
    • How
      Injection under the skin

    Trial-validated subcutaneous (under the skin) GH-releasing doses of 1.5-3 mcg/kg in healthy volunteers 6; the ~100 mcg fixed-dose practice figure aligns with the lower 1.5 mcg/kg trial dose.

  2. GH stimulation testing

    1-2 mcg/kg (2 mcg/kg is maximally effective)

    • How often
      Single administration
    • For how long
      One-time test to trigger GH release
    • How
      Injection or drip into a vein

    Trial-established near-maximal GH-releasing intravenous dose; produced a larger GH rise than equimolar GHRH in 12 healthy young volunteers 6.

Adjusting your dose

You're at the right dose if…

  • Better sleep quality and waking refreshed
  • Improved recovery from workouts
  • Gradual improvements in body composition
  • Stable energy throughout the day

Consider going up if…

  • You've tolerated the starting dose well for 2+ weeks with minimal side effects
  • You're not noticing expected effects like improved sleep or recovery
  • Your goals require more aggressive GH optimization under supervision

Go down if…

  • You experience significant water retention that doesn't resolve
  • Numbness or tingling in hands becomes bothersome
  • Joint pain or stiffness develops
  • Hunger spikes become difficult to manage

The ceiling: 200 mcg three times daily (600 mcg total)—though desensitization is more likely at higher doses

Reconstitution, in plain words

How do I mix Hexarelin?

Peptides usually arrive as a freeze-dried powder in a small vial. “Reconstitution” just means adding sterile water back in so you can measure a dose. Here's how it works for Hexarelin:

What you need

  • Bacteriostatic water (BAC water)—the preservative keeps it safe for multiple uses
  • Insulin syringes (29-31 gauge)—thin needles mean less discomfort
  • Alcohol swabs for cleaning vial tops and injection sites
  • Your Hexarelin powder vial

A worked example

If you have a 5mg vial and add 2.5mL of BAC water, you get a concentration of 2mg/mL (2000mcg/mL). So every 0.05mL (5 units on an insulin syringe) equals 100mcg of Hexarelin.

Working out your dose

For a 100mcg dose at 2000mcg/mL concentration: draw 0.05mL (5 units on a standard insulin syringe). For 200mcg: draw 0.1mL (10 units).

Or let the calculator do it

Three quick questions — your vial, your water, your dose — and it tells you the exact syringe mark. “Find dose amount” is preloaded with Hexarelin's recorded schedule.

HexarelinSingle dose in trials; 1-3 times daily in research practice

How much peptide is in your bottle?

Look at the label on the vial. It’s the number next to the unit — like "5 mg". Labeled in IU? Switch the unit to IU.

Type a number to continue.
0

Injection sites & technique

Where do I inject Hexarelin?

The best spots

  • Belly fat area (about 2 inches away from your belly button)
  • Front or outer thigh (middle section)
  • Back of the upper arm

How to do it, step by step

  • Wash your hands thoroughly with soap and water
  • Clean the injection site with an alcohol swab and let it air dry completely
  • Pinch about an inch of skin to create a fold
  • Insert the needle at a 45-90 degree angle (45 if you're lean, 90 if you have more tissue)
  • Push the plunger slowly and steadily
  • Wait 5 seconds before removing the needle
  • Apply light pressure if needed—don't rub

Subcutaneous (under the skin) injection (just under the skin)—the easiest and most common method for self-administration

Timing

When do I take Hexarelin?

Best time of day

On an empty stomach—either first thing in the morning (30-60 minutes before eating) or before bed (2-3 hours after your last meal). The GH pulse is much stronger when you haven't eaten recently 7.

With or without food?

Food significantly blunts the GH response. Always inject at least 30 minutes before eating, or 2-3 hours after a meal. Fatty foods especially interfere with absorption.

Taking it with other peptides

Hexarelin pairs well with CJC-1295 (without DAC) or Mod GRF 1-29 for synergistic GH release. 7816 If stacking, inject at the same time. Space out from other GHRP peptides to avoid excessive GH spikes or desensitization.

The honest list

What side effects could Hexarelin cause?

Common — usually mild

These show up most often. They usually fade as your body adjusts.

Less common

Worth knowing about, but most people never see these.

Serious — stop and get medical help

Rare, but if any of these happen, stop and contact a medical professional.

  • Allergic reaction

    Rare but possible with any peptide. Watch for hives, significant swelling (especially face/throat), or difficulty breathing.

    What to do STOP immediately and seek emergency medical care. This is extremely rare but requires immediate attention.

Week by week

What should I expect from Hexarelin, and when?

  1. Days 1-7

    You might notice
    • Increased hunger 30-60 minutes after injection
    • Possible mild water retention (slightly puffy hands or face)
    • Better sleep quality, especially with evening dosing
    • Mild tingling in hands or feet (this is normal)
    • Perhaps some initial fatigue as your body adjusts
    What's normal
    • Hunger spikes are very common and expected
    • Minor fluid retention that may add 1-2 lbs
    • Feeling a bit different but not dramatically changed yet
    What's next
    • Stick with your protocol—it takes time to see results
    • Note any side effects to track your response
    • Ensure you're injecting on an empty stomach for best results

  2. Weeks 2-4

    You might notice
    • Sleep quality improvements becoming more consistent
    • Initial side effects (water retention, tingling) often diminish
    • Better workout recovery
    • Possibly some improvement in skin quality
    • More stable energy levels
    What's normal
    • Hunger effects may decrease as your body adapts
    • Water weight stabilizes or decreases
    • Subtle but noticeable improvements in how you feel
    What's next
    • Consider adding a second daily dose if tolerating well
    • Stay consistent with timing and empty-stomach dosing
    • Track body composition changes, not just scale weight

  3. Weeks 5-8

    You might notice
    • More noticeable changes in body composition
    • Improved muscle tone and recovery
    • Skin and hair quality improvements
    • Better exercise performance
    • Consistent sleep benefits
    What's normal
    • Progressive but not dramatic changes
    • Feeling established in your routine
    • Side effects should be minimal at this point
    What's next
    • Continue through week 8-12 as planned
    • Consider blood work to check IGF-1 (a growth signal your liver releases in response to growth hormone) levels if desired
    • Plan your off-cycle period to maintain receptor sensitivity

  4. Weeks 9-12+

    You might notice
    • Peak benefits from your cycle
    • Solid improvements in body composition if diet and training are on point
    • Some users may notice diminishing effects (desensitization)
    • Overall sense of improved vitality and recovery
    What's normal
    • Some plateau in effects is normal toward end of cycle
    • Benefits tend to persist for some time after stopping
    • Ready to cycle off and give receptors a break
    What's next
    • Plan 4-8 weeks off to restore receptor sensitivity
    • Maintain your results with good nutrition and training
    • Evaluate whether to do another cycle based on your response

How to tell it's actually working

Sleep and Recovery

  • Falling asleep more easily
  • Deeper, more restorative sleep
  • Waking up feeling refreshed
  • Faster recovery from workouts
  • Less muscle soreness after training

Body Composition

  • Gradual reduction in body fat, especially around midsection
  • Improved muscle tone and definition
  • Clothes fitting differently (looser in waist, tighter in shoulders)
  • Better workout pumps
  • Increased strength over time

General Well-Being

  • More stable energy throughout the day
  • Improved skin quality (some users report a 'glow')
  • Better mood and mental clarity
  • Faster healing from minor injuries
  • Improved exercise tolerance

Not seeing anything? The usual reasons

  • Taking with food or too soon after eating—always inject on an empty stomach for optimal GH release
  • Inconsistent dosing—GH peptides work best with consistent, regular use
  • Poor quality peptide from unreliable source—always verify third-party testing (COAs)
  • Desensitization from prolonged use—take a 4-8 week break if effects diminish
  • Improper storage degraded the peptide—check if solution is crystal clear before using
  • Unrealistic expectations—Hexarelin enhances your body's GH release, but you still need good nutrition and training

Is it right for you?

Who should avoid Hexarelin?

Do not use it if…

  • You are pregnant or might become pregnant—effects on fetal development are unknown
  • You are breastfeeding—the peptide could pass into breast milk
  • You have active cancer or history of cancer—GH can potentially stimulate tumor growth
  • You have uncontrolled diabetes—GH can affect blood sugar regulation
  • You've had an allergic reaction to any synthetic peptide

Be extra careful if…

  • You have diabetes or pre-diabetes—monitor blood sugar closely as GH affects glucose
  • You take insulin or diabetes medications—may need dosage adjustments
  • You have a history of carpal tunnel syndrome—GH can worsen symptoms
  • You have joint problems—water retention may temporarily increase discomfort
  • You're taking medications that affect GH or cortisol (the stress hormone) levels

When to stop

  • Any signs of allergic reaction—stop immediately and seek medical help
  • Severe or worsening water retention that doesn't improve with dose reduction
  • Persistent numbness or tingling that affects daily activities
  • Blood sugar issues that don't stabilize
  • Any side effect that significantly impacts your quality of life
  • You've completed your planned cycle length

Hexarelin is a research compound, not an FDA-approved medication. Never start, stop, or change your dosing without guidance from a qualified healthcare provider. This information is for educational purposes only—not medical advice.

What it mixes badly (and well) with

Medications

  • Avoid
    Insulin

    GH affects blood sugar. If you're on insulin, monitor closely and work with your doctor, as dose changes may be needed.

  • Avoid
    Diabetes medications

    Same concerns as with insulin. GH can raise blood sugar temporarily. Monitor and consult your doctor.

  • Check first
    Corticosteroids (prednisone, etc.)

    High-dose steroids can blunt (weaken) the GH response and reduce Hexarelin's benefits.

  • Check first
    Thyroid medications

    GH and thyroid hormones affect each other. Usually safe, but check thyroid levels if you take thyroid replacement.

Other peptides

  • OK together
    CJC-1295 (no DAC) / Mod GRF 1-29

    Works well together: the GHRH analog (a drug that copies the brain's GH-releasing signal) amplifies Hexarelin's GH release. Can be injected together.

  • OK together
    Ipamorelin

    Both are GHRPs (growth-hormone-releasing peptides). Using them together may cause too much GH release and make the body stop responding faster (desensitization). Better to choose one or alternate.

  • Check first
    GHRP-6

    Works in a similar way to Hexarelin. Combining may raise side effects like hunger and water retention without matching benefits.

  • OK together
    BPC-157

    Safe to combine. BPC-157 focuses on healing and has different mechanisms. Can complement Hexarelin's recovery benefits.

Supplements

  • OK together
    Arginine

    Can support GH release. Safe to take, though Hexarelin is already very potent on its own.

  • OK together
    GABA

    May enhance GH release, especially when taken before bed. Safe to combine.

  • OK together
    Melatonin

    Safe and may support the natural nighttime GH pulse. Good for evening dosing protocols.

  • OK together
    Creatine

    No interaction concerns. Can support the muscle-building benefits of enhanced GH.

Who it tends to suit

Growth Hormone Optimization

Hexarelin is one of the most potent GH-releasing peptides available. It triggers strong, natural pulses of growth hormone from your pituitary (the master hormone gland at the base of the brain), mimicking the way your body released GH when you were younger. This makes it ideal for those looking to restore youthful GH levels 689.

Heart Health Support

Unlike most other GH peptides, Hexarelin protects the heart directly by binding to CD36 (a docking site on heart cells). Research shows it can protect heart cells from damage, reduce inflammation, and even help prevent the scarring that follows heart injury 135.

Body Composition Improvement

The robust GH pulses triggered by Hexarelin enhance fat burning while supporting lean muscle. Research in obese models showed it increased lipid oxidation in fat tissue and reduced fat accumulation in the liver—all while improving insulin sensitivity (how well your body responds to insulin) 2.

Athletic Recovery

Growth hormone is essential for tissue repair and recovery. Hexarelin's ability to stimulate strong GH release makes it popular among athletes looking to bounce back faster from training. The improved sleep quality many users report also supports recovery.

The safety picture overall

Hexarelin has been studied in human trials and shows a generally favorable safety profile at research doses. 69 The most common effects relate to its strong GH-releasing action: temporary hunger spikes, 14 mild water retention, 15 and occasional tingling in the hands. Importantly, research suggests Hexarelin has direct cardioprotective effects that may add a margin of safety for cardiovascular health 15.

Hexarelin has more human trial data than many research peptides, including Phase 1-2 studies examining its effects on GH release, heart function, and metabolism. 69101116 However, large-scale Phase 3 trials and FDA approval have not been pursued. Always work with a healthcare provider when using research compounds.

Keeping it good

How do I store Hexarelin?

Before mixing (powder)

Keep your Hexarelin powder in the refrigerator (36-46°F / 2-8°C) for short-term storage. For long-term storage (over 2 months), keep in the freezer (-4°F / -20°C). Store in the original sealed vial away from light. Properly stored powder can remain stable for 2+ years when frozen.

After mixing (liquid)

Once mixed with bacteriostatic water, refrigerate at 36-46°F (2-8°C). Never freeze the reconstituted solution—freezing destroys the peptide structure. Keep away from light and use within 28-30 days.

Signs it has gone bad

  • Cloudy or hazy appearance (should be crystal clear)
  • Visible particles floating or settled at the bottom
  • Color changes—any yellowing or discoloration means toss it
  • Clumping or gel-like consistency

Not our opinion — the published record

What the studies actually found about Hexarelin

2020

Hexarelin targets neuroinflammatory pathways to preserve cardiac morphology and function in a mouse model of myocardial ischemia-reperfusion

This study showed hexarelin significantly improved heart function under conditions that mimic a heart attack. Treated mice had less heart scarring, lower inflammation markers, and better cardiac output (how much blood the heart pumps). This suggests hexarelin protects the heart through anti-inflammatory pathways involving the autonomic nervous system (the body's automatic control system).

McDonald H, Peart J, Kurniawan ND, et al.

2021

Stimulation of endogenous pulsatile growth hormone secretion by activation of growth hormone secretagogue receptor reduces fat accumulation and improves insulin sensitivity in obese mice

Hexarelin increased pulsatile (natural-rhythm) GH release in obese mice, leading to less visceral (belly) fat, less fat buildup in the liver, and better insulin sensitivity (how well the body responds to insulin), all without changing IGF-1 levels. This suggests hexarelin helps metabolic health through direct GH effects.

Huang Z, Lu X, Huang L, et al.

2017

The Growth Hormone Secretagogue Hexarelin Protects Rat Cardiomyocytes From in vivo Ischemia/Reperfusion Injury Through Interleukin-1 Signaling Pathway

Hexarelin protected heart cells from damage caused by blocked and restored blood flow. It worked by reducing harmful inflammation through the IL-1 pathway (an inflammation signal), switched on when it attaches to the GHSR-1a receptor on heart cells. The heart-protecting effects were even slightly better than ghrelin's.

Huang J, Li Y, Zhang J, et al.

2014

The cardiovascular action of hexarelin

This broad review established that hexarelin acts on the cardiovascular system directly through two receptors (docking sites): GHSR-1a and CD36. The CD36 route seems especially important for heart protection, which makes hexarelin unique among GH-releasing drugs for heart support.

Mao Y, Tokudome T, Kishimoto I

1997

Growth hormone-releasing peptides

Review of the GHRP class (GH-releasing peptides) in animals and humans. The GH-releasing effect is synergistic with GHRH (the combined effect is bigger than the sum of the parts). It partly desensitizes (the body responds less over time), more with continuous infusion and less with on-and-off dosing. It is also blunted by inhibiting influences including glucose, free fatty acids, neurotransmitters (brain messengers) and glucocorticoids (steroid hormones).

Ghigo E, Arvat E, Muccioli G, Camanni F

1996

Short-term administration of intranasal or oral Hexarelin, a synthetic hexapeptide, does not desensitize the growth hormone responsiveness in human aging

Healthy elderly subjects were given hexarelin through the nose, 1.25 mg three times daily for 8 days, or by mouth, 20 mg three times daily for 15 days. They kept their GH response to the peptide. IGF-I and IGFBP-3 (a carrier protein for IGF-I) rose slightly and neither treatment caused any side effect. On-and-off dosing did not cause the somatotrope (GH-making cell) response to desensitize.

Ghigo E, Arvat E, Gianotti L, Grottoli S, Rizzi G, Ceda GP, Boghen MF, Deghenghi R, Camanni F

If this isn't the right fit

What people use instead of Hexarelin

Growth hormone release without strong hunger effects

  • Ipamorelin
  • Tesamorelin
  • CJC-1295

Heart protection through other routes

  • BPC-157
  • TB-500
  • GHK-Cu

Weight loss focus

  • Semaglutide
  • Tirzepatide
  • AOD-9604

Your questions

Hexarelin FAQ

How is Hexarelin different from other growth hormone (GH)-releasing peptides like GHRP-2 or GHRP-6?

Hexarelin is one of the strongest growth hormone-releasing peptides. 681617 What really sets it apart is its ability to protect the heart through CD36 (a docking site on heart cells that other peptides don't use). 5 It also causes less hunger than GHRP-6, though more than Ipamorelin. Think of it as a strong all-rounder with added heart benefits.

Why do I need to inject on an empty stomach?

Food, especially carbs and fats, triggers insulin release. Insulin and growth hormone kind of compete with each other—when insulin is elevated, your body suppresses GH release. By injecting when you haven't eaten for a few hours, you maximize the GH pulse that Hexarelin triggers. 7 Eating right after injection is fine, but wait at least 30 minutes.

Will Hexarelin make me hungry?

Yes, increased hunger is one of the most common effects, usually hitting about 30-60 minutes after injection. This is because Hexarelin activates the same receptors as ghrelin, your hunger hormone. 14 Most users find this effect decreases after the first week or two. Planning your injection around meal times can help manage this.

How long can I use Hexarelin before taking a break?

Most protocols suggest 8-12 weeks on, followed by 4-8 weeks off. This cycling approach helps prevent desensitization—where your receptors become less responsive to the peptide. 79 If you notice effects diminishing toward the end of your cycle, that's a sign your body needs a break.

Can Hexarelin help with heart health?

Research strongly suggests yes. Multiple studies show Hexarelin protects heart cells from damage, reduces inflammation in heart tissue, and may even help prevent scarring after heart injury. 13 These effects work through CD36 (a docking site on heart cells), which is separate from its growth hormone-releasing effects. 51011 It's one of the few peptides with documented heart-protecting properties.

Should I stack Hexarelin with other peptides?

Hexarelin pairs very well with GHRH analogs (modified versions of a natural molecule) like CJC-1295 (without DAC) or Mod GRF 1-29. The combination is synergistic—you get a bigger GH pulse than with either alone. 7816 However, stacking with other GHRPs (like GHRP-2 or GHRP-6) isn't usually recommended as it can increase side effects and speed up desensitization without proportional benefits.

Is Hexarelin FDA approved?

No, Hexarelin is not FDA approved in the United States. It remains a research compound. While it has been studied in human trials (Phase 1-2), 691016 it hasn't gone through the full approval process. It's primarily available through research chemical suppliers and compounding pharmacies.

What results can I realistically expect?

With consistent use, good nutrition, and training, most users report improved sleep quality, faster recovery from workouts, and gradual improvements in body composition over 8-12 weeks. You won't transform overnight—think of it as optimizing your body's natural GH production. The heart-protective effects happen behind the scenes and aren't something you'll 'feel' directly.

17 sources

References

Every numbered marker on this page points to one of these. Same sources, same numbering as the Hexarelin research profile on Peptide Initiative.

  1. Hexarelin targets neuroinflammatory pathways to preserve cardiac morphology and function in a mouse model of myocardial ischemia-reperfusionMcDonald H, Peart J, Kurniawan ND, et al. · 2020
  2. Stimulation of endogenous pulsatile growth hormone secretion by activation of growth hormone secretagogue receptor reduces fat accumulation and improves insulin sensitivity in obese miceHuang Z, Lu X, Huang L, et al. · 2021
  3. The Growth Hormone Secretagogue Hexarelin Protects Rat Cardiomyocytes From in vivo Ischemia/Reperfusion Injury Through Interleukin-1 Signaling PathwayHuang J, Li Y, Zhang J, et al. · 2017
  4. Hexarelin modulates lung mechanics, inflammation, and fibrosis in acute lung injuryZambelli V, Rizzi L, Delvecchio P, et al. · 2021
  5. The cardiovascular action of hexarelinMao Y, Tokudome T, Kishimoto I · 2014
  6. Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, after intravenous, subcutaneous, intranasal, and oral administration in manGhigo E, Arvat E, Gianotti L, Imbimbo BP, Lenaerts V, Deghenghi R, Camanni F · 1994
  7. Growth hormone-releasing peptidesGhigo E, Arvat E, Muccioli G, Camanni F · 1997
  8. Mechanisms underlying the negative growth hormone (GH) autofeedback on the GH-releasing effect of hexarelin in manArvat E, Di Vito L, Gianotti L, Ramunni J, Boghen MF, Deghenghi R, Camanni F, Ghigo E · 1997
  9. Short-term administration of intranasal or oral Hexarelin, a synthetic hexapeptide, does not desensitize the growth hormone responsiveness in human agingGhigo E, Arvat E, Gianotti L, Grottoli S, Rizzi G, Ceda GP, Boghen MF, Deghenghi R, Camanni F · 1996
  10. Acute cardiovascular and hormonal effects of GH and hexarelin, a synthetic GH-releasing peptide, in humansBisi G, Podio V, Valetto MR, Broglio F, Bertuccio G, Del Rio G, Arvat E, Boghen MF, Deghenghi R, Muccioli G, Ong H, Ghigo E · 1999
  11. Growth hormone-independent cardiotropic activities of growth hormone-releasing peptides in normal subjects, in patients with growth hormone deficiency, and in patients with idiopathic or ischemic dilated cardiomyopathyBroglio F, Benso A, Valetto MR, Gottero C, Quaranta L, Podio V, Arvat E, Bobbio M, Bisi G, Ghigo E · 2001
  12. GH-releasing activity of Hexarelin, a new growth hormone releasing peptide, in infant and adult ratsDeghenghi R, Cananzi MM, Torsello A, Battisti C, Muller EE, Locatelli V · 1994
  13. Characterization of ghrelin receptor activity in a rat pituitary cell line RC-4B/CFalls HD, Dayton BD, Fry DG, Ogiela CA, Schaefer VG, Brodjian S, Reilly RM, Collins CA, Kaszubska W · 2006
  14. Feeding behavior during long-term hexarelin administration in young and old ratsBresciani E, Pitsikas N, Tamiazzo L, Luoni M, Bulgarelli I, Cocchi D, Locatelli V, Torsello A · 2008
  15. Aspects of growth hormone deficiency and replacement in elderly hypopituitary adultsFeldt-Rasmussen U, Wilton P, Jonsson P · 2004
  16. Hexarelin-induced growth hormone, cortisol, and prolactin release: a dose-response studyMassoud AF, Hindmarsh PC, Brook CG · 1996
  17. Hexarelin decreases slow-wave sleep and stimulates the secretion of GH, ACTH, cortisol and prolactin during sleep in healthy volunteersFrieboes RM, Antonijevic IA, Held K, et al. · 2004

Want the deep science?

Read the full Hexarelin research profile

Every claim on this page traces back to the research database behind Peptide Initiative — studies, citations, clinical trial data, and the technical detail we deliberately left out here.

Open the research profile

More growth hormone guides

This guide is education, not medical advice. Hexarelin is a research compound that is not FDA-approved for human use. Talk to a clinician before taking anything.